Product
name: Exendin (5-39)
Catalog#: 1208009
Sequence:
TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
Quantity: 5mg
Purity: 95% by
HPLC
Counter
ion: Trifluoacetate
Format: Lyophilized
powder
Description: We previously reported that
exendin (5-39) (Ex), an antagonist of the GLP-1 receptor, improved memory
impairment in ¥â-amyloid protein-treated rats. In this study, we investigated
effects of Ex on synaptic transmission through astrocytic GLT-1 in the
hippocampus. Continuous intracerebroventricular (i.c.v.) administration of Ex
for 1-week increased GLT-1 protein levels in the hippocampus of 4-week-old male
Wistar rats. For electrophysiological studies, hippocampal slices were prepared
from these Ex-treated rats or vehicle-treated rats. Ex decreased fEPSP decay
time, and increased the input–output relation and decreased the paired-pulse
ratio in the dentate gyrus (DG). Furthermore, Ex inhibited long-term depression
but not long-term potentiation in the DG. These effects were prevented by DHK, a
specific GLT-1 inhibitor. In addition, glutamate uptake was significantly
increased by Ex-treatment in cultured astrocytes. These results suggest that Ex
modulates synaptic transmission and plasticity through astrocytic glutamate
uptake in the DG.
Uniprot
ID:
Usage: For
Scientific Research Use Only, Not for Human Use.
Reference:
Brain Research. Volume 1505, 10 April 2013, Pages
1–10.