Product
name: PepFect 14(PF14)
Sequence:
Stearyl-AGYLLGKLLOOLAAAALOOLL
Modifications: n-terminal Stearic
Acid, c-terminal amide,O,
ornithine,
Purity: 95% by
HPLC
Counter
ion: Trifluoacetate
Format: Lyophilized
powder
Description: PepFect 14, a novel
cell-penetrating peptide for oligonucleotide delivery in solution and as solid
formulation.PepFect 14 (PF14) is a modified version of our previously reported
peptide, stearyl-transportan10 (stearyl-TP10), where we utilized ornithines and
leucines instead of lysines and isoleucines. PF14 demonstrates remarkable
splice-correction activity in two different cell models including mdx mouse
myotubes, a cell culture model of DMD, even in the presence of serum.
Furthermore, the feasibility of formulating these nanocomplexes into solid
formulation was investigated and the efficiency and stability of such
formulations were assessed.
Usage: For
Scientific Research Use Only, Not for Human Use.
Reference:
Nucleic Acids Res. 2011;39:5284–5298.