Sequence:

H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(γ-Glu-palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH

Family Description:

Liraglutide is a long-acting analog of GLP-1 that has been developed for the treatment of type 2 diabetes. The palmitoyl group facilitates non-covalent binding to albumin which provides a circulating reservoir for liraglutide's GLP-1 activity. Binding to albumin hinders degradation by DPP IV and neutral endopeptidase (NEP), thereby prolonging the half-life of the circulating complex.


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