Product name: Cyclic glycine-proline (cGP)

Synonyms: cyclo-glycyl-proline (cyclic GP),

Sequence: c(Gly- Pro)

Modifications: head-to-tail lactam,

Purity: 95% by HPLC

Format: White powder

Description: Cyclo-glycyl-proline (cyclic Gly-Pro) is an endogenous DKP that may be derived from GPE. Cyclic glycine-proline (cGP), a metabolite of IGF-1, can normalise IGF-1 function by showing its efficacy in improving the recovery from ischemic brain injury in rats and inhibiting the growth of lymphomic tumours in mice. Further investigation in cell culture suggested that cGP promoted the activity of IGF-1 when it was insufficient, but inhibited the activity of IGF-1 when it was excessive. Mathematical modelling revealed that the efficacy of cGP was a modulated IGF-1 effect via changing the binding of IGF-1 to its binding proteins, which dynamically regulates the balance between bioavailable and non-bioavailable IGF-1.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Sci Rep. 2014 Mar 17;4:4388.

British Journal of Pharmacology (2009), 157, 881–891.