Product name: Semax

Sequence: Met-Glu-His-Phe-Pro-Gly-Pro

Purity: 95% by HPLC

Format: White powder

Description: One of the drugs that is effectively employed currently in cerebral stroke therapy is the Semax (Met-Glu-His-Phe-Pro-Gly-Pro), which is a synthetic peptide consisting of a fragment of ACTH(4–7) and the C-terminal tripeptide Pro-Gly-Pro (PGP). Studies have shown that Semax promotes the survival of neurons during hypoxia and glutamate neurotoxicity. It also shows neuroprotective properties and contributes to mitochondrial stability under stress induced by the deregulation of calcium ion flow. The action of Semax causes the inhibition of nitric oxide synthesis, improves the trophic supply of the brain, and protects the nervous system effectively against diseases of the optic nerve. This peptide also possesses nootropic activity.

Compound ID: 122178

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

BMC Genomics. 2014 Mar 24; 15:228.

Mol Biol (Mosk). 2013 May-Jun; 47(3):461-6.

Mol Biol (Mosk). 2011 Nov-Dec; 45(6):1026-35.

Cell Mol Neurobiol. 2010 Jan; 30(1):71-9.