Product name: GLYX 13

Synonyms: TPPT-amide, GLYX-13 peptide, GLYX13,

Sequence: Thr-Pro-Pro-Thr-NH2

Purity: 95% by HPLC

Counter ion: Acetate

Format: Lyophilized powder

Description: GLYX-13, a tetrapeptide (TPPT-amide), was found to readily cross the blood-brain barrier and modulate the NMDA receptor in a glycine-like fashion when examined pharmacologically and electrophysiologically. When GLYX-13 was administered to rats at 0.5-1.0mg/kg i.v., a significant enhancement in learning was observed using a hippocampus-dependent trace eye blink conditioning paradigm. These data indicate that the Glyxins are a new class of NMDA receptor modulators that may have therapeutic potential. Based on the broad agonist range in vitro and the potent cognitive-enhancing properties in a valid in vivo model of learning, GLYX-13 is a new drug candidate with potential for the treatment of cognitive disorders.

Compound ID: 14539800

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Biomed Res Int. 2014; 2014:234295.

Neurobiol Aging. 2011 Apr; 32(4):698-706.

Neurosci Biobehav Rev. 2011 Oct; 35(9):1982-8.

Neuropharmacology. 2005 Dec;49(7):1077-87.