Product name: Reversin 121

Synonyms: chemosensitizer 121, R121 peptide, N(α)-Boc-l-Asp(OBn)-l-Lys(Z)-OtBu, (S)-tert-butyl 2-((S)-4-(benzyloxy)-2-(tert-butoxycarbonylamino)-4-oxobutanamido)-6-(benzyloxycarbonylamino)hexanoate,

Sequence: Boc-Asp(OBn)-Lys(Z)-OtBu

Purity: 95% by HPLC

Counter ion: Trifluoroacetate

Format: Lyophilized powder

Description: N(α)-Boc-l-Asp(OBn)-l-Lys(Z)-OtBu (reversin 121, 1), an inhibitor of the P-gp ABC transporter, was used to conceive compounds inhibiting the drug efflux occurring through the Hoechst 33342 and daunorubicin transport sites of P-gp, respectively H and R sites.

Compound ID: 9939298

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

J Med Chem. 2010 Sep 23;53(18):6720-9.

Biochem Pharmacol. 1999 Aug 15;58(4):571-86.