Product name: Tkip

Synonyms: tyrosine kinase inhibitor peptide,

Sequence: WLVFFVIFYFFR

Purity: 95% by HPLC

Counter ion: Trifluoroacetate

Format: Lyophilized powder

Description: Our laboratory recently designed a short 12-mer peptide, WLVFFVIFYFFR, which binds to the autophosphorylation site of JAK2, resulting in inhibition of its autophosphorylation as well as its phosphorylation of IFNGR subunit IFNGR-1. The JAK2 tyrosine kinase inhibitor peptide (Tkip) did not bind to or inhibit tyrosine phosphorylation of vascular endothelial growth factor receptor or phosphorylation of a substitute peptide by the protooncogene tyrosine kinase c-Src. Tkip, as with SOCS-1, also inhibited EGFR autophosphorylation.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

J Immunol. 2007 Apr 15;178(8):5058-68.

J. Immunol. 2004, 172: 7510-7518.