Product name: Peptide G16
Sequence: PRRYTIAALLSPYSWS
Purity: 95% by HPLC
Counter ion: Trifluoroacetate
Format: Lyophilized powder
Description: Transthyretin, a plasma transport protein that is also relatively abundant in cerebrospinal fluid, has been shown to bind to A¥â, inhibit aggregation, and reduce its toxicity. Previously, we identified strand G of transthyretin as a specific A¥â binding domain. In this work we further explore and define the necessary features of this binding domain. We demonstrate that peptides derived from transthyretin bind A¥â and inhibit its toxicity. We also show that, although both transthyretin and transthyretin-derived peptides bind A¥â and inhibit toxicity, they differ significantly in their effect on A¥â aggregation.
Usage: For Scientific Research Use Only, Not for Human Use.
Reference:
ACS Chem. Neurosci., 2014, 5 (7), pp 542–551.