Product name: MT-II

Synonyms: Melanotan II,Melanotan-II,

CAS NO.: 121062-08-6

Sequence: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH2

Modifications: N-terminal acetylation, C-terminal amide, lactam Asp-Lys

M.W: C50H69N15O9

M.F.: 1024.18

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Further developments in α-MSH analogs included structure-function experiments that have helped to elucidate the amino acid residues necessary for receptor binding affinity of α-MSH for melanocortin receptors. These experiments have identified the “essential core” of native α-MSH peptide as His6-Phe7-Arg8-Trp9. From the identification of this four amino acid core, a highly potent cyclic analog, MTII, was constructed from only 7 residues of the native α-MSH sequence with cyclization to restrict the conformation — adding further stability to the structure — while maintaining targeting affinity. Structurally, the sequence of MTII, Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH2, retains the core residues, while forming a lactam bridge through cyclization of the aspartic acid and lysine side chains. This cyclic analog is over 100-fold more potent than the linear α-MSH peptide in lizard skin assays. Several analogs of MTII have been prepared in an effort to increase biological activity and impart receptor subtype specificity.

Compound ID: 92432

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Journal of Andrology, 2004;25(5):683-691.

J Med Chem. 1989 Dec; 32(12):2555-61.

Biochemistry. 1988 Oct 18; 27(21):8181-8.