Product name: VEGF mimicking peptide QK

Sequence: Ac-KLTWQELYQLKYKGI-NH2

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: QK binds to VEGF receptors in vitro and show that it is a potential agonist for angiogenesis. A stable helical structure of the core region of the QK region appears to be a key requisite for its ability to bind the VEGF receptor. The basis of the QK helical fold seems to reside on the presence of amino acids with intrinsic helix preference and on the amphipathic nature of the helix, which allows a number of medium range ionic, polar, and hydrophobic interactions on opposite faces of the peptide. Moreover, QK peptide, which is composed by only 15 natural amino acids and whose structure in pure water has been derived with a good backbone resolution, could represent a model for further folding studies.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14215-20.