Product name: VEGF receptor-binding peptide(VR-BP)

Synonyms: VR-BP,

Sequence: GGGKLTWQELYQLKYKGI

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: VR-BP exhibits pro-angiogenic effects on endothelial cells when presented in soluble form.soluble VR-BP exhibits agonistic effects similar to VEGF, but covalent immobilization of VR-BP leads to antagonism of VEGF signaling.This context dependence between soluble and immobilized VR-BP was identified using a SAM array platform to rigorously control cell-substrate interactions, and systematically probe for the effects of immobilized VR-BP on endothelial cell attachment, proliferation, and tubulogenesis. Based on these findings we hypothesize that covalent immobilization of VR-BP, and potentially other ligands that bind growth factor receptors, may be capable of interfering with growth factor receptor dimerization and subsequent signal transduction. These results suggest a new mechanism for regulating growth factor signaling that may be useful to control specific biological processes, such as angiogenesis.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

J Transl Med. 2009;7:41.

Chemistry. 2008;14(14):4164–6.

Proc Natl Acad Sci U S A. 2005;102(40):14215–20.