Product
name: Pep-c19
Sequence:
VVNKLIRNNKMNC
Purity: 95% by
HPLC
Counter
ion: Trifluoacetate
Format: Lyophilized
powder
Description: Recently, 30Kc19 protein has
attracted attention because it was the first cell-penetrating protein that has
been found in insect hemolymph. Here, we report a cell-penetrating peptide
derived from 30Kc19 protein, VVNKLIRNNKMNC, which efficiently penetrates cells
when supplemented to medium for mammalian cell culture. Moreover, like other
CPPs, this ¡°Pep-c19¡± also efficiently delivered cell-impermeable cargo proteins,
such as green fluorescent protein (GFP) into cells. In addition to the in vitro
system, Pep-c19 exhibited the cell-penetrating property in vivo. When Pep-c19
was intraperitoneally injected into mice, Pep-c19 successfully delivered cargo
proteins into various organ tissues with higher efficiency than the 30Kc19
protein itself, and without toxicity. Our data demonstrates that Pep-c19 has a
great potential as a cell-penetrating peptide that can be used as a therapeutic
tool to efficiently deliver different cell-impermeable cargo molecules into the
tissues of various organs.
Usage: For
Scientific Research Use Only, Not for Human Use.
Reference:
Process
Biochemistry.Volume 49, Issue 9, September 2014, Pages
1516–1526.