Product
name: Hymenochirin-1Pa
Sequence:
LKLSPKTKDTLKKVLKGAIKGAIAIASMA-NH2
Modifications: c-terminal
amide,
Purity: 95% by
HPLC
Counter
ion: Trifluoacetate
Format: Lyophilized
powder
Description: Hymenochirin-1Pa
(LKLSPKTKDTLKKVLKGAIKGAIAIASMA-NH2) is a host-defense peptide first isolated
from skin secretions of the frog Pseudhymenochirus merlini (Pipidae).
Hymenochirin-1Pa shows broad spectrum anti-bacterial activity, including high
potency against multidrug-resistant clinical isolates of Staphylococcus aureus,
Acinetobacter baumannii, and Stenotrophomonas maltophilia. The peptide also
shows high cytotoxic potency against human non-small lung adenocarcinoma A549
cells, breast adenocarcinoma MDA-MB-231 cells, and colorectal adenocarcinoma
HT-29 cells but its therapeutic potential as an anti-cancer agent is limited by
moderate hemolytic activity against human erythrocytes and lack of selectivity
for tumor cells. Increasing cationicity of the peptide by substituting the Asp9
residue by either l-Lys (K) or d-Lys (k) has relatively minor effects on
antimicrobial and anti-tumor potencies but the [D9k] analog is non-hemolytic
LC50 > 400 ¥ìM. Thus, [D9k]hymenochirin-1Pa may serve as a template for the
design of non-toxic antimicrobial agents for use against multidrug-resistant
pathogenic bacteria.
Usage: For
Scientific Research Use Only, Not for Human Use.
Reference:
Peptides.Volume
61, November 2014, Pages 114–121.