Product
name: TRS23 (145-167)
Sequence:
TTAAPPTPSATTPAPPSSSAPPE
Purity: 95% by
HPLC
Counter
ion: Trifluoacetate
Format: Lyophilized
powder
Description: The strains of P. gingivalis
(W50 and 381), A. actinomycetemcomitans (Y4 and 67), S. gordonii (DL1), and S.
mutans (GS5) are highly sensitive to this peptide at 1.5-3.0 microM
concentrations, suggesting that the proline-rich repeat sequence is a potent
bactericidal agent for oral pathogens. The bactericidal activity of the
proline-rich repeat sequence suggests that bacterial colonization, facilitated
by the adsorbed salivary mucins on tooth surface, could be partly controlled and
cleared by proteolytically degraded proline-rich peptides of MG2 in saliva
before the colonized organisms turn into pathogens. It appears that the
poly-L-proline II helix is the biologically active backbone conformation for
bactericidal activity of the tandem repeat sequences of salivary
MG2.
Usage: For
Scientific Research Use Only, Not for Human Use.
Reference:
Arch Biochem
Biophys. 1998 Aug 15;356(2):197-206.
Biochemistry.
1996 Apr 9; 35(14):4314-25.