Product
name: B cell epitope
PPGMRPP
Sequence:
PPGMRPP
Purity: 95% by
HPLC
Counter
ion: Trifluoacetate
Format: Lyophilized
powder
Description: The main B cell epitope,
PPGMRPP, of the Sm autoantigen against which the majority of antibodies in
patients with systemic lupus erythematosus is directed, was coupled to the
Lys-N(epsilon)H(2) groups of the carrier in four copies and the resulting
conjugate Palm-SOC(4)-II-Sm(4) was subjected to animal immunizations without
utilizing any adjuvant. The induced immune response was comparable with that
produced when Ac-SOC(4)-II-Sm(4) was administered in animals following the
conventional immunization protocol of complete/incomplete Freund's adjuvant.
High titers of anti-Palm-SOC(4)-II-Sm(4) antibodies were generated, which
recognize the priming immunogenic conjugate, as well as reconstituted Sm mimics
but not the carrier alone.
Uniprot
ID:
Usage: For
Scientific Research Use Only, Not for Human Use.
Reference:
Vaccine. 2007
Sep 17;25(37-38):6708-12.