Product name: Htt epitope peptide

Sequence: EKLMKAFESLKSFQ

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Using peptide SPOT arrays, we identified the minimal binding epitope to be EKLMKAFESLKSFQ, comprising the N-terminal residues 5–18 of Htt and including the first residue of the poly-Gln stretch.  The Htt epitope peptide adopts a purely α-helical structure in the complex with αHtt-VL and is bound at the base of the complementarity-determining regions (CDRs) at the concave β-sheet that normally gives rise to the interface between the VL domain and its paired VH (variable domain Ig heavy chain) domain, while only few interactions with CDR-L1 and CDR-L3 are formed.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

Journal of Molecular Biology. Volume 414, Issue 3, 2 December 2011, Pages 337–355.