Product name: SFLLRN

Sequence: Ser-Phe-Leu-Leu-Arg-Asn-NH2

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Protease-activated receptor-1 (PAR1) is activated by the cleavage of the extracellular N-terminal domain by proteases such as thrombin and plasmin. This cleavage releases a tethered ligand (SFLLRN) that activates the receptor and initiates a signaling cascade through Gαq/11, Gαi/o, or Gα12/13 G-proteins. Free SFLLRN activates Protease-activated receptor-1 (PAR1) independent of receptor cleavage and has been used to probe PAR1 function in various cells and tissues.  SFLLRN-NH2-induced increases in astrocytic and neuronal calcium signals are blocked when the cells are pretreated with the glial metabolic blocker, fluorocitrate. Protease-activated receptor 1 agonist SFLLRN induced latent TGFβ1 activation and Smad3 phosphorylation in human gingival fibroblasts.

Usage: For Scientific Research Use Only, Not for Human Use.

Reference:

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J Lab Clin Med. 2000 Jan;135(1):66-72.

Biochemistry. 1999 Feb 23; 38(8):2486-93.

Thromb Haemost. 1993 Dec 20;70(6):1019-23.